Il Nuovo Postiglione - Arsenal face must-win match against Premier League pacesetters Liverpool

Two under pressure managers face off at the London Stadium as Julen Lopetegui aims to quell disquiet among the West Ham support against Erik ten Hag's Manchester United.

AFP Sport looks at the key talking points ahead of the weekend action.

Depleted Arsenal face Liverpool test

Arsenal were tipped to push Manchester City all the way again this season after twice coming so close to a first Premier League title since 2003/04.

But it is Liverpool who lead the way after a near flawless start to Arne Slot's reign.

The Gunners shock 2-0 defeat to Bournemouth last week leaves them four points behind the Reds and three adrift of second-placed City.

Arsenal could be without three of their most important players with William Saliba suspended, Martin Odegaard sidelined by an ankle injury and Bukayo Saka a doubt due to a hamstring problem.

Defenders Riccardo Calafiori and Jurrien Timber could also be missing and Mikel Arteta has called on the Arsenal fans to be the 12th man on Sunday.

"The place has to be rocking here against Liverpool to give us all the possible energy that they can," he said.

Liverpool, with 11 wins from 12 matches in all competitions, are flying under their new manager but victory against Arsenal would be the clearest statement yet that they are genuine title contenders.

Man Utd hunt goals against struggling West Ham

Manchester United showed encouraging signs of life in their comeback win against Brentford last week, with Alejandro Garnacho, Rasmus Hojlund and Marcus Rashford linking up well in attack.

It was a welcome sight for beleaguered manager Ten Hag, whose team had failed to find the net in their previous three league matches.

Hojlund scored his first Premier League goal of the season while Rashford, playing on the right of the attack, looked sharp, setting up Garnacho's goal.

But only winless Crystal Palace, Southampton and Ipswich have scored fewer than United's seven goals in eight league games.

Just 10 games into his reign in east London, Lopetegui is already under scrutiny after a second-half collapse in a 4-1 defeat at rivals Tottenham last weekend.

A return of eight points from eight games is not what Hammers fans expected after spending £120 million ($156 million) strengthening their squad in the transfer window.

Pressure mounts for winless quartet

For the first time in English top-flight history, four clubs remain without a win from their opening eight games of a season.

It is difficult to predict a win for any of the three sides in the relegation zone this weekend -- bottom team Wolves face Brighton away while Southampton travel to Manchester City and Crystal Palace host Tottenham.

Winless Ipswich, fourth from bottom, could put some distance between themselves and the drop zone if they beat Brentford.

It is a particularly sharp fall from grace for Palace, who finished 10th last season after a storming end to the campaign.

The toothless London side have scored just five goals so far this season -- the lowest tally in the league -- and manager Oliver Glasner admits they are short of confidence.

Speaking after Monday's 1-0 defeat against Nottingham Forest, he said: "I don't think it's a tactical problem, it's a mentality problem, it's a lack of confidence and so this is what we have to change."

Everton and West Ham already have a four-point cushion over the bottom four, who can ill afford to be cut adrift in a mini-league to avoid the drop.

Fixtures

Friday

Leicester v Nottingham Forest (1900 GMT)

Saturday (1400 unless stated)

Aston Villa v Bournemouth, Brentford v Ipswich, Brighton v Wolves, Manchester City v Southampton, Everton v Fulham (1630)

Sunday (1400 unless stated)

Chelsea v Newcastle, Crystal Palace v Tottenham, West Ham v Manchester United, Arsenal v Liverpool (1630)

A.Mariconda--INP