Il Nuovo Postiglione - Elizabeth Holmes: Silicon Valley's fallen star

The rise and fall of Holmes, who in January was convicted of defrauding investors of her biotech startup, is a heavily chronicled saga that prompted a hard look at her methods but also the unseemly aspects of startup life.

In many ways Holmes fit the image of a Silicon Valley entrepreneur, from her dark-colored turtleneck sweaters that evoked tech legend and Apple founder Steve Jobs to her dropping out of California's elite Stanford University.

But it has all come crashing down with the tech star, who is now pregnant, set to surrender herself in April of next year to begin serving time.

The fundamental question surrounding her case was always whether Holmes was a true visionary who simply failed, as she claimed on the stand, or a skilled self-promoter who took advantage of a credulous context to commit fraud.

Her story begins in the US capital Washington, with her birth to a Congressional staffer mother and a father whose online biography says he was once an executive at Enron -- an energy company that collapsed in a massive fraud scandal.

She won admission to Stanford, and there began work on cutting-edge biomedical initiatives, founding in 2003 what would become Theranos when she was just 19.

Part of Holmes's ability to convince her backers was her apparent deep personal commitment -- she applied for her first patent while still at university and after dropping out, convinced her parents to let her use her tuition savings to build the company.

- 'Youngest woman self-made billionaire' -

By the end of 2010 she had raised a whopping $92 million in venture capital for Theranos, which she pledged was developing machines that could run a gamut of diagnostic tests on a few drops of blood.

Over the next couple years she assembled what one news report called the "most illustrious board in US corporate history," including former secretaries of state Henry Kissinger and George Shultz as well ex-Pentagon chief Jim Mattis.

"Sharp, articulate, committed. I was impressed by her. That didn't take the place of having the device prove itself," said Mattis in a surprise appearance on the stand.

Theranos hype kicked up another gear in 2014 and in the span of just over a year, a turtleneck-wearing Holmes appeared on the covers of Fortune, Forbes, Inc. and T: The New York Times Style Magazine.

Forbes gave her a $4.5 billion net worth in 2014, which was based on her half ownership of Theranos, and noted: "Youngest woman on Forbes 400; Youngest woman self-made billionaire."

This glowing coverage had an impact on Theranos investors like venture capitalist Chris Lucas who told Holmes' trial the Fortune article made him "proud we were involved, very proud of Elizabeth."

But there were some things that didn't end up in those glowing reports that gushed with statements like "Steve Jobs had massive ambition, but Holmes's is arguably larger."

- Silicon Valley sexism? -

For one, she personally put the logos of pharma giants Pfizer and Schering-Plough onto Theranos reports hailing its own blood-testing technology, which were then shared with investors.

That was done without the companies' permission and was a key piece of the prosecution's argument that she deliberately tried to inflate Theranos's credibility in order to win over backers.

She also kept secret the machines' failings and the fact that once Theranos began to do diagnostics on real patients, some of the tests were done using the same equipment sold to standard labs.

Ultimately though, it was a series of Wall Street Journal reports starting in 2015 -- which Holmes tried to kill by appealing to the paper's owner and Theranos investor Rupert Murdoch -- that set the company's collapse in motion.

Holmes's case also raised questions about why she was prosecuted, but not other tech CEOs who engaged in the "fake it until you make it" Silicon Valley method or other bad behavior.

Ellen Pao, the former CEO of Reddit and critic of tech industry discrimination, argued in a New York Times opinion piece that sexism bears some blame.

She noted that WeWork's Adam Neumann and Uber co-founder Travis Kalanick raised billions with hype, while there have been allegations of racism and sexism at Tesla and misleading claims about vaping from Juul's leaders.

Holmes "should be held accountable for her actions as chief executive of Theranos," Pao wrote.

But "it can be sexist to hold her accountable for alleged serious wrongdoing and not hold an array of men accountable for reports of wrongdoing or bad judgement," she added.

F.Criscuolo--INP