Il Nuovo Postiglione - Netanyahu says 'many signs' Khamenei is dead after Israel, US attack Iran

The strikes prompted Tehran to fire off a missile barrage that sent people running for cover in cities across the Middle East.

Iranian authorities urged residents to evacuate the capital, a city of 10 million, while the country's Red Crescent society said that at least 201 people had been killed in the strikes and more than 700 wounded.

The Iranian judiciary said one strike that hit a school in the south killed 108 people, although AFP was unable to access the site to verify the toll or the circumstances surrounding the incident.

Meanwhile, the UAE reported one civilian dead and damage from missiles in Dubai and Abu Dhabi, as blasts from Tehran's retaliatory salvo and air defences intercepting it also echoed over Israel, Saudi Arabia, Bahrain, Qatar, Jordan and Kuwait.

"This morning, in a powerful surprise strike, the compound of the tyrant Ali Khamenei was destroyed in the heart of Tehran... and there are many signs that this tyrant is no longer alive," Netanyahu said in a televised statement.

Cheers could be heard on Tehran's streets after reports of the death, according to witnesses.

Plumes of black smoke had been seen over Tehran's Pasteur district, where Khamenei usually resides, with Israel's Channel 12 network reporting 30 bombs were dropped on the compound.

Foreign Minister Abbas Araghchi had earlier told NBC News that Khamenei was alive "as far as I know", adding that "all high-ranking officials are alive".

Also asked about Khamenei's health, foreign ministry spokesman Esmail Baqaei told the BBC he was "not in a situation to confirm anything", but "the whole system, the whole nation is focused on defending (our) national integrity".

In a sign that the fighting was far from over, Netanyahu said "thousands" of targets would be hit over the coming days, while Iran's top security official vowed a fierce reprisal.

"This morning we eliminated senior figures in the ayatollahs' regime -- commanders in the Revolutionary Guards and senior officials in the nuclear programme -- and we will continue," Netanyahu said.

Ali Larijani, head of Iran's Supreme National Security Council, said: "The brave soldiers and the great nation of Iran will teach an unforgettable lesson to the international oppressors."

- 'Barbaric' -

Tehran residents had been going about their usual business when the strikes began. Security forces quickly flooded the streets, shops pulled down their shutters and few pedestrians risked venturing out, an AFP journalist saw.

"I saw with my own eyes two Tomahawk missiles flying horizontally toward targets," a Tehran office worker told AFP before communications and internet access were cut.

The Red Crescent said 24 of Iran's 31 provinces were affected by the strikes.

Across Israel, city streets stood deserted as residents took cover in shelters while the blasts of intercepted Iranian missiles reverberated overhead. Emergency services reported two people injured.

Iran's Revolutionary Guards, meanwhile, radioed ships to say the Strait of Hormuz, a strategic waterway, was shut, according to the EU's naval mission and Iranian media.

- 'Eliminating imminent threats' -

The attacks came after US President Donald Trump expressed frustration at Iran's stance in negotiations over its nuclear and missile programmes.

Trump said Washington's goal was "eliminating imminent threats" from Iran, while Israel's Prime Minister Benjamin Netanyahu said the operation was to remove an "existential threat".

"We are going to destroy their missiles and raze their missile industry to the ground," Trump said.

He also told Iranians the "hour of your freedom is at hand", urging them to rise up and "take over your government".

It was the first US military action of this scale apparently aimed at toppling a foreign government since the 2003 invasion of Iraq.

Netanyahu echoed Trump's call, telling Iranians that the time had come to "cast off the yoke of tyranny".

Israel's army chief Lieutenant General Eyal Zamir said the operation was "taking place at a completely different scale" than the 12-day war it fought against Iran in June, which the US briefly joined.

A military statement called the operation "an extensive attack", saying it was the largest military air raid in the history of the Israeli Air Force".

Iran's Revolutionary Guards said their "missiles and drones have struck the headquarters of the US Navy's Fifth Fleet in Bahrain and other American bases in Qatar and the United Arab Emirates, as well as military and security centres in the heart of the occupied territories (Israel)".

Iran, Iraq, Kuwait, Syria, the UAE and Israel all closed their airspaces to civilian traffic, at least in part, and multiple airlines cancelled flights to the Middle East.

- Blasts across Gulf -

Residents and AFP correspondents in the Emirati, Qatari and Bahraini capitals heard multiple rounds of explosions from Iran's retaliatory strikes.

In Qatar, people fled in panic as a falling missile plunged into a residential neighbourhood, erupting in a fireball as it hit the street.

And in Abu Dhabi, the UAE's capital, golfers were stunned to see dozens of projectiles flying overhead.

In Bahrain's capital Manama, residents were hurriedly evacuated from the Juffair district housing the US Navy's Fifth Fleet.

"When we heard the sounds, we cried out of fear," said Jana Hassan, a 15-year-old student who was in the area. "I will never forget the sound of those loud blasts."

Two witnesses told AFP they heard an explosion and saw a plume of smoke rising from Dubai's famed man-made island The Palm, with authorities reporting four injured.

The foreign ministry of Oman, a mediator in recent US-Iran talks, called "on all parties to immediately cease military operations" and urged the UN Security Council to impose a ceasefire.

burs/smw/dcp

D.Campanella--INP